Trulicity (dulaglutide)

What is it?

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Trulicity, the brand name for Dulaglutide, is a diabetic medication that is of the same group of medications as Liraglutide (Saxenda) and Semaglutide (Ozempic, Rybelsus and Wegovy). Although not yet licensed for weight loss, Dulaglutide can currently be prescribed for weight loss in the UK by a qualified pharmacist as a weekly injection. It works in the same way as Ozempic, and is a good alternative during the current Ozempic shortage.

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How does it work?

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The medication mimics a natural hormone already found in your body (GLP-1). It works in three key ways to reduce your appetite.

 

1. It blocks a key hunger hormone telling your brain that you are hungry, whilst also helping to reduce leptin resistance (a hormone which can help off-set weight gain by increasing satiety aka fullness, and speed up your metabolism to help regulate the levels of fatty tissue in your body). This also helps stop the weight from coming straight back on when you stop the jab.

2. It slows down the gastric emptying process, meaning that your body takes longer to process food and it is fuller for longer. This means your body does not need as much intake as normal as it works off the food it has.

3. The medication helps to speed up your metabolism and increase fat burning by reducing glucogen & reducing insulin resistance. This promotes normal blood glucose levels, the liver metabolism of glucose and helps adipose tissue burn fat in a safe and controlled method without causing a sugar-crash. This avoids the urges for quick-fix sugary foods.

 

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How do I use it?

The medication comes as 4 x pre-filled injectable pens. You inject yourself in an area where you can pinch a good amount of meat (aka subcutaeneous fat). This can be the stomach area, the notorious love handle areas, top of the thighs or even the upper arms. You use a new pen once a week, disposing of the pen after each injection. Each course of 4 pens would last for 4 weeks at a time.

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What is the dosage?

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The starting dose is is 0.75mg per week for 4 weeks. Official titration guidelines from the manufacturer then recommend 1.5mg per week for 4 weeks, 3mg for 4 weeks, and then 4.5mg per week for continual maintenance. If you have previously used Trulicity within the past 3 months and wish to order a higher dose than the starting dose of 0.75mg, we will require proof of previous usage uploaded via our Health Form or sent to us via email.

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What about side effects?

Like any new medication introduced to your body, your body will have to adjust to it. Some people get mild side effects, such as headaches, nausea, dry mouth or tiredness. These side effects are generally mild and are transient – which means they will go after a few days once your body has adjusted.

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Some clients experience no side effects, whilst the majority of our own clients experience LESS side effects than Ozempic. We will send you aftercare information on how to deal with any potential side effects, along with the Patient Information Leaflet which goes into greater detail.

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Everyone is different. You may not experience any side effects, you may experience one side effect or several side effects.

Common Side Effects:

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• Nausea

• Headaches

• Dry Mouth

• Constipation

• Loose Stool

• Tiredness

• Stomach Cramps

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Please do not hesitate to contact us if you need any support on dealing with side effects. We are more than happy to advise you.

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Adverse Effects:

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Adverse effects are rare but they are something you should be aware of.

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Adverse effects may include:

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• Palpitations / Fast Heart Rate

• Pancreatitis

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If you experience or feel that you may be experiencing these adverse effects, please stop using the medication & contact 111. When you are safe to do so, please contact us.

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Anaphylaxis:

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There have been no documented cases of an anaphylactic reaction to Liraglutide, Dulaglutide or Semaglutide but as this is a new medication being introduced to your body, we want to make you aware of the possible signs of anaphylaxis.

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If you experience swelling of the lips/tongue/throat, difficulty breathing, tightness in the chest, a severe rash or severe itching, discontinue use immediately and call 999.​

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Who can use it?

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The medication can be used for those with a BMI over 25. We take into account a range of factors such as:

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• BMI

• Medical History

• Current Medication

• Body measurements

• Eating habits

• Past diets

• Current exercise levels

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The programme is not suitable for:

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Under 18’s

Ladies who are breastfeeding, pregnant or actively trying to get pregnant.

Type 1 diabetics

Anyone with a history of pancreatitis or thyroid tumours

Anyone with direct family members who have had thyroid cancer

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How much weight will I lose?

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During the current initial clinical trials by the manufacturer, the average weight loss has been calculated as between 10lbs and 18lbs. Everyone is different, so your weight loss may be more or less. Try not to compare yourself to others losing weight – focus on yourself, your goals and your progress. – your safety is paramount.

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How many pens will I need?

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This depends on what dose you are on, how well you take to the medication and your overall target weight. You will therefore only need a minimum of ONE course (4 pens) per month.

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Anything else?

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Please note that this medication is not yet licensed for weight loss. It is a prescription-only medication and should be prescribed by a qualified pharmacist. Your full medical history and circumstances should be taken into account to ensure safety & suitability. We prescribe and dispense only from within the UK.